I got this question when I spoke earlier this month the EJTU meeting. It’s a good one. I’d just shown the group a video of trout taking sulphur emergers. The rises were regularly timed and showy/splashy. You could also see the bugs in the air.
The question was: When you get to the river and you see a scene like that, do you automatically go to a a dry/dropper? A: No. I will start with a wet fly team of three, and two of them will likely be sulphur patterns. There’s a lot to unpack here in terms of that decision. In this particular video, it was late afternoon in June. The rise forms clearly said the fish were on emergers. The time of year, time of day, rise forms, and visible bugs (sulphurs, whose nymphs are in the drift a good long time before emergence) indicated that the trout were taking their food just below the surface. A dry/dropper might get you some takes, but why not feed the fish like they’re already eating? Which is, subsurface, just below the film. A wet fly team of three fits that bill perfectly.

Note that a dry-dropper may be a better method for presenting just under the surface with different hatches. A midge pupa in winter would be a good example of that.